Creamer won the 100m hurdles and 300m hurdles events with her times of 17.44 and 51.35.
Greene finished first in the 100m and 200m races with her times of 13.56 and 28.39.
Hillsboro posted a time of 11:56.09 to win the 4 x 800m relay.
Seyfang claimed the shot put and discus event wins with her throws of 37-1 and 138-4. Seyfang's discus result represents an Ohio No. 2 and a new pr. The senior's shot put effort is an Ohio tie for No. 19 for the 2018 outdoor season.